Probiophage DF

Probiophage DF

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Probiophage DF capsules | Designs for Health

Dairy-free bacteriophage/probiotic combination formula.*
Probiophage DF™ is a specialized bacteriophage formula with four types of phages (as the proprietary bacteriophage blend PrePhage™) along with seven strains of probiotics. This product is designed to support the proliferation of beneficial bacteria throughout the small and large intestines in order to promote healthy GI and immune function.*
This dairy-free formulation is featured in a delayed-release capsule to increase intact delivery to the small intestine by protecting these organisms from stomach acid.*

What is a Bacteriophage?*

  • Bacteriophages, or simply phages – whose name means to eat or devour in Greek – are benevolent viruses that exclusively infect bacteria. Phages are the most abundant naturally occurring organisms on earth and are relatively benign. We are surrounded by phages, as they can be found virtually everywhere, including in soil, food and drinking water. A single drop of seawater can hold millions of phages and the human body contains billions of them. They prey only on bacteria, never human cells, and bacteria have trouble becoming immune to them. They are considered to be a safe and effective way to help reduce the density of specific pathogenic bacterial populations.*

  • Great interest in bacteriophages was sparked in 1919 when it was demonstrated that they could be used to treat infectious diseases, but in the U.S. that interest waned with the advent of antibiotics. However, research continued in the former Soviet Union, where bacteriophages are widely used to this day.*

  • Phages continuously change and adapt with their host bacteria to destroy them more effectively. Thus, phage therapy may help to eliminate the vicious cycle of bacteria developing a resistance to antibiotics.*


  • The most abundant naturally occurring organisms on earth*
  • Widely distributed in water, soil, animals and humans and consumed daily in common foods*
  • A type of virus that can infect bacterial cells, replicate, and cause the destruction of the bacterium*
  • Replication occurs by one of two cycles, either the lytic or lysogenic cycle*
  • Lytic phages are highly target-specific – activity confined to one or a limited number of bacteria*
  • Provide a non-host derived immunity*
  • Lytic phages are completely safe, considered GRAS (through review of published scientific literature, and based on their common use in food), with some having been approved by the FDA for use in foods as a means to control foodborne pathogens*
  • Eli Lily first sold as an OTC in the 1920s*
  • Very specific phages classify as prebiotics*

How Bacteriophages Destroy Target Bacteria*

  • Lytic phages invade bacterial cells and replicate within the bacterium, disrupting bacterial metabolism and causing the bacterium to lyse.*
  • Replicated bacteriophages are then able to spill out and attack other existing bacteria.*
  • As the population of the target bacterium declines, the numbers of the corresponding phage will also decline.*
  • The application of phages to bacteria-containing environments makes a quantitative difference, not a qualitative one, since phages already exist in many environments, including water, soil, food, and among normal human flora.*

PrePhage is a proprietary blend of T4 Bacteriophages, which are:

  • Lytic phages*
  • Specific to E. coli*
  • Shown to rapidly decrease numbers of E. coli*
  • Shown to significantly enhance the growth of beneficial bacteria in the GI such as Bifidobacteria, Lactobacillus, and others*.

Bacteriophages as Prebiotics*

  • Highly specific bacteriophages may be classified as prebiotics since they enhance the growth of beneficial bacteria in the gastrointestinal tract. Beneficial GI bacteria such as bifidobacteria, lactobacillus and others, are in a constant battle for food and space. Inhibition of the growth of neutral or potentially harmful bacteria creates an availability of space and resources to allow the growth of beneficial organisms.*

Advantages of PrePhage™ Over Traditional Prebiotics*

  • Most other prebiotics are non-digestible fibers that often produce the negative side effect of gas and bloating. They may be required in large doses and for prolonged periods, and may not be effective in the small bowel since their activity is localized to the large intestine. In some people they may also increase the growth of unwanted bacteria in the GI tract.*

In contrast, PrePhage™ has the following features:

  • No fermentation and therefore no gas or bloating*
  • Independent of environmental conditions*
  • Effective in small doses*
  • Efficacious within hours*
  • Active in small and large intestines*

Highlights of PrePhage™*

  • Has narrow host ranges; only interacts with select bacteria*
  • Enhances growth of good bacteria*
  • Commonly found in foods we consume*
  • Non-GMO*
  • GRAS (Generally Recognized As Safe)*

The combination of phages with probiotics helps to:

  • Increase the survivability of probiotics*
  • Create more space for good bacteria by reducing counts of unwanted bacteria*
  • Provide a natural way to shift intestinal bacteria toward more beneficial organisms*

How to Take:

  • As a dietary supplement, take one capsule per day with a meal, or as directed by your health care practitioner.*

Probiophage DF 60 capsules | Designs for Health

Serving Size: 1 capsule

Servings Per Container: 60 capsules

% Daily Value
PrePhage™ Proprietary Bacteriophage Prebiotic
15 mg
Proprietary Probiotic Blend (Bifidobacterium bifidum, Lactobacillus acidophilus, Bifidobacterium longum, Lactobacillus rhamnosus, Bifidobacterium breve, Lactobacillus casei, Streptococcus thermophilus)
5 billion cfu

Other Ingredients: Tapioca dextrin, medium chain triglycerides; delayed release capsule (hydroxypropyl methylcellulose [HPMC], water, gellan gum).

Recommended Use: As a dietary supplement, take one capsule per day with a meal, or as directed by your health care practitioner.

Warning: Color, size or shape may appear different between lots.

Avoid exposure to high heat and direct sunlight; keep refrigerated after opening.

Viable organisms are at time of manufacture

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  • Disclaimer

*Your results may vary from those listed above.

*These statements have not been evaluated by the Food and Drug Administration.
*This product is not intended to diagnose, treat, cure or prevent any disease.

Since we do not know everything about your medical history and medications, please consult with your health care practitioner before implementing any new protocols and supplements. Do not construe any information listed on this site as a substitute for actual medical advice. The info you receive from us is not intended to replace medical advice by your doctor. Forrest Health, Inc. does not dispense medical advice, prescribe, or diagnose illness. We offer nutritional programs and supplements that support your health. The views and nutritional advice expressed by Forrest Health, Inc. are not intended to be a substitute for conventional medical service. If you have a medical condition, see your physician of choice.