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Methylation Support

Methylation Support Supplements

B12 (Methylcobalamin, Hydroxycobalamin, Adenosylcobalamin)
Methyl Folate, 5-MTHF (5-Methyltetrahydrofolic)
SAMe, S-Adenosyl Methionine

The role of the methylation cycle in your body

The methylation cycle is the ideal pathway to focus on for nutritional genetic analysis because the places where mutations occur is well defined and it is clear where supplements can be added to go around these mutations.

The function of the methylation cycle is essential for a number of critical reactions in the body. One consequence of genetic weaknesses (mutations) in this pathway is increased risk factors for a number of serious health conditions. Defects in methylation lay the appropriate groundwork for the further assault of environmental and infectious agents resulting in a wide range of conditions including diabetes, cardiovascular disease, thyroid dysfunction, neurological inflammation, chronic viral infection, neurotransmitter imbalances, atherosclerosis, cancer, aging, schizophrenia, decreased repair of tissue damage, improper immune function, neural tube defects, Down’s syndrome, Multiple Sclerosis, Huntington’s disease, Parkinson’s disease, Alzheimer’s disease, and autism, Inflammation, bacterial, and viral infection

Methylation uses the process of donating ‘Methyl Groups’ to a substrate.

A Methyl Group = 1 Carbon bound to 3 Hydrogens = CH3
Methyl groups substrates are commonly, but not limited to:

DNA and RNA,
chemicals,
Neurotransmitters and hormones,
immune cells,
nerves

Functions of Methylation:

Turn on and off genes (gene regulation)
Process chemicals and toxins (biotransformation)
Build neurotransmitters (dopamine, serotonin, epinephrine)
Process hormones (estrogen)
Build immune cells (T cells, NK cells)
DNA and RNA synthesis
Produce energy (CoQ10, carnitine, ATP)
Produce protective myelination coating on nerves

Methylation can be disturbed by:

Lack of cofactors driving methylation forward (zinc, magnesium, B6)
Medications (antacids)
Specific nutrients depleting methyl groups (niacin)
Environmental toxicity, heavy metals, chemicals (acetylaldehyde, arsenic, mercury)
Excessive substrate (feedback inhibition)
Genetic mutations

Signs of methylation issues

Hair	loss, brittle
Brain	anxiety, depression, ADHS, Autism, memory loss, Alzheimer's, insomnia, restless legs, shizophrenia, bipolar disorders
Eyes	teary, redness
Ears	Tinnitus
Thyroid	hypothyroid
Heart	hypotension, strokes, clots
Gut	IBS
Skin	easy bruising, rashes, eczema, vitiligo, psoriasis, poor wound healing, pigmentation
Nails	brittle, ridges
Hormone	low estrogen, testosterone
Energy	fatigue
Allergies	food, celiac
Fertility	neural tube defects, infertility, miscarriages
Muscles	fibromyalgia, muscle pains
Immune	fungus, virus, sinusitis

Genetic SNP Mutations

Many people have mutations in their methylation pathways. Because of this it is necessary to use the 5-MTHF form. If you are not sure, we offer easy to perform genetic tests for methylation.

MTHFR C677T -- 0% loss; +- 40% loss; ++ 70% loss of function
MTHFR A1298C -- 0% loss; +- 20% loss; ++ 40% loss of function

Supplementation

Remember, restarting the mehtylation pathway can start major detoxification of metals, chemicals and viruses. So your mantra should be "Start low, go slow." This means start with low does and slowly increase until you get to the desired dose

It is desirable to help open detoxifcation pathways with homeopathic, botanical and nutraceuticals when up-regulating the methylation pathway. For advise on this you can schedule an appointment with Dr. Forrest.

We off the absolutely highest quality folic acid, Methyltetrahydrofolic acid (5-MTHF), B12 and SAMe supplements from the best companies. We are happy to assist if you need help.

These nutritional supplements are highly suitable for those on the Dr. Amy Yaskow or Rich Van Konyenburg protocols.

Genetic Testing

There are currently a variety of ways to get your testing done. Once the testing is done the results of your methylation pathway must be analyzed to produce an individualized supplement program..