Methylation Support Supplements
- B12 (Methylcobalamin, Hydroxycobalamin, Adenosylcobalamin)
- Methyl Folate, 5-MTHF (5-Methyltetrahydrofolic)
- SAMe, S-Adenosyl Methionine
Methylation uses the process of donating ‘Methyl Groups’ to a substrate.
A Methyl Group = 1 Carbon bound to 3 Hydrogens = CH3
Methyl groups substrates are commonly, but not limited to:
DNA and RNA,
Neurotransmitters and hormones,
Functions of Methylation:
Turn on and off genes (gene regulation)
Process chemicals and toxins (biotransformation)
Build neurotransmitters (dopamine, serotonin, epinephrine)
Process hormones (estrogen)
Build immune cells (T cells, NK cells)
DNA and RNA synthesis
Produce energy (CoQ10, carnitine, ATP)
Produce protective myelination coating on nerves
Methylation can be disturbed by:
Lack of cofactors driving methylation forward (zinc, magnesium, B6)
Specific nutrients depleting methyl groups (niacin)
Environmental toxicity, heavy metals, chemicals (acetylaldehyde, arsenic, mercury)
Excessive substrate (feedback inhibition)
Signs of methylation issues
|Brain||anxiety, depression, ADHS, Autism, memory loss, Alzheimer's, insomnia, restless legs, shizophrenia, bipolar disorders|
|Heart||hypotension, strokes, clots|
|Skin||easy bruising, rashes, eczema, vitiligo, psoriasis, poor wound healing, pigmentation|
|Hormone||low estrogen, testosterone|
|Fertility||neural tube defects, infertility, miscarriages|
|Muscles||fibromyalgia, muscle pains|
|Immune||fungus, virus, sinusitis|
Genetic SNP Mutations
Many people have mutations in their methylation pathways. Because of this it is necessary to use the 5-MTHF form. If you are not sure, we offer easy to perform genetic tests for methylation.
- MTHFR C677T -- 0% loss; +- 40% loss; ++ 70% loss of function
- MTHFR A1298C -- 0% loss; +- 20% loss; ++ 40% loss of function
Remember, restarting the mehtylation pathway can start major detoxification of metals, chemicals and viruses. So your mantra should be "Start low, go slow." This means start with low does and slowly increase until you get to the desired dose
It is desirable to help open detoxifcation pathways with homeopathic, botanical and nutraceuticals when up-regulating the methylation pathway. For advise on this you can schedule an appointment with Dr. Forrest.
We off the absolutely highest quality folic acid, Methyltetrahydrofolic acid (5-MTHF), B12 and SAMe supplements from the best companies. We are happy to assist if you need help.
These nutritional supplements are highly suitable for those on the Dr. Amy Yaskow or Rich Van Konyenburg protocols.
There are currently a variety of ways to get your testing done. Once the testing is done the results of your methylation pathway must be analyzed to produce an individualized supplement program..
- Order your test. Genetic Testing
Methylation Made Easy Videos