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Methylation Support

Methylation Support Supplements

  • B12 (Methylcobalamin, Hydroxycobalamin, Adenosylcobalamin)
  • Methyl Folate, 5-MTHF (5-Methyltetrahydrofolic)
  • SAMe, S-Adenosyl Methionine

 

The role of the methylation cycle in your body
The methylation cycle is the ideal pathway to focus on for nutritional genetic analysis because the places where mutations occur is well defined and it is clear where supplements can be added to go around these mutations.
 
The function of the methylation cycle is essential for a number of critical reactions in the body. One consequence of genetic weaknesses (mutations) in this pathway is increased risk factors for a number of serious health conditions. Defects in methylation lay the appropriate groundwork for the further assault of environmental and infectious agents resulting in a wide range of conditions including diabetes, cardiovascular disease, thyroid dysfunction, neurological inflammation, chronic viral infection, neurotransmitter imbalances, atherosclerosis, cancer, aging, schizophrenia, decreased repair of tissue damage, improper immune function, neural tube defects, Down’s syndrome, Multiple Sclerosis, Huntington’s disease, Parkinson’s disease, Alzheimer’s disease, and autism, Inflammation, bacterial, and viral infection

 

 

Methylation uses the process of donating ‘Methyl Groups’ to a substrate. 

  • A Methyl Group = 1 Carbon bound to 3 Hydrogens = CH3 

  • Methyl groups substrates are commonly, but not limited to: 

    • DNA and RNA, 

    • chemicals, 

    • Neurotransmitters and hormones, 

    • immune cells, 

    • nerves 

 

Functions of Methylation: 

  1. Turn on and off genes (gene regulation) 

  2. Process chemicals and toxins (biotransformation) 

  3. Build neurotransmitters (dopamine, serotonin, epinephrine) 

  4. Process hormones (estrogen) 

  5. Build immune cells (T cells, NK cells) 

  6. DNA and RNA synthesis

  7. Produce energy (CoQ10, carnitine, ATP) 

  8. Produce protective myelination coating on nerves

Methylation can be disturbed by: 

  1. Lack of cofactors driving methylation forward (zinc, magnesium, B6) 

  2. Medications (antacids) 

  3. Specific nutrients depleting methyl groups (niacin) 

  4. Environmental toxicity, heavy metals, chemicals (acetylaldehyde, arsenic, mercury) 

  5. Excessive substrate (feedback inhibition) 

  6. Genetic mutations 

 

Signs of methylation issues

Hair loss, brittle
Brain anxiety, depression, ADHS, Autism, memory loss, Alzheimer's, insomnia, restless legs, shizophrenia, bipolar disorders
Eyes teary, redness
Ears Tinnitus
Thyroid hypothyroid
Heart hypotension, strokes, clots
Gut IBS
 Skin easy bruising, rashes, eczema, vitiligo, psoriasis, poor wound healing, pigmentation
 Nails  brittle, ridges
 Hormone  low estrogen, testosterone
 Energy  fatigue
 Allergies  food, celiac
 Fertility  neural tube defects, infertility, miscarriages
 Muscles  fibromyalgia, muscle pains
 Immune  fungus, virus, sinusitis
   

  

Genetic SNP Mutations

Many people have mutations in their methylation pathways. Because of this it is necessary to use the 5-MTHF form. If you are not sure, we offer easy to perform genetic tests for methylation.

  • MTHFR C677T        -- 0% loss; +- 40% loss; ++ 70% loss of function
  • MTHFR A1298C      -- 0% loss; +- 20% loss; ++ 40% loss of function

 

Supplementation

Remember, restarting the mehtylation pathway can start major detoxification of metals, chemicals and viruses. So your mantra should be "Start low, go slow." This means start with low does and slowly increase until you get to the desired dose

It is desirable to help open detoxifcation pathways with homeopathic, botanical and nutraceuticals when up-regulating the methylation pathway. For advise on this you can schedule an appointment with Dr. Forrest.

We off the absolutely highest quality folic acid, Methyltetrahydrofolic acid (5-MTHF), B12 and SAMe  supplements from the best companies. We are happy to assist if you need help.

These nutritional supplements are highly suitable for those on the Dr. Amy Yaskow or Rich Van Konyenburg protocols.

 

Genetic Testing

There are currently a variety of ways to get your testing done. Once the testing is done the results of your methylation pathway must be analyzed to produce an individualized supplement program..

 

Understanding MTHFR

 

Methylation Made Easy Videos

 

 

Products

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5-Methyl Folate 1000mcg 90 tabs
5-Methyl Folate 1000mcg 90 tabs
SKU: PLFB026
5-Methyl Folate 1000mcg 90 tabs | Protocol For Life Balance - 5-Methyl Folate 1000mcg utilizes a patented form of (read more)

5-Methyl Folate 1000mcg 90 tabs | Protocol For Life Balance - 5-Methyl Folate 1000mcg utilizes a patented form of 5-MTHF with superior bioavailability.*

(hide)
$18.00
Market price: $20.00 save 10%
5-MTHF 1, 5, 15mg
5-MTHF 1, 5, 15mg
SKU: THRN007
5-MTHF 1, 5, 15 mg 60 vcaps | Thorne Research - MTHF is an active, tissue-ready form of folate.* It's an essential B vitamin (read more)

5-MTHF 1, 5, 15 mg 60 vcaps | Thorne Research - MTHF is an active, tissue-ready form of folate.* It's an essential B vitamin that supports methylation.*

(hide)
$19.00
5-MTHF 120 caps
5-MTHF 120 caps
SKU: PRTY020
5-MTHF 120 caps | Priority One - 5-MTHF is the most biologically active form of folate. Not having enough 5-MTHF can (read more)

5-MTHF 120 caps | Priority One - 5-MTHF is the most biologically active form of folate. Not having enough 5-MTHF can cause anemia.*

(hide)
$34.00
5-MTHF 15 mg 30 caps
5-MTHF 15 mg 30 caps
SKU: THRN0071

5-MTHF 15 mg 30 caps | Thorne Research - Active folate supplementation for mood, heart health, fetal development and nerve support.*

$56.00
Market price: $57.00 save 2%
Acetyl-L-Carnitine 250 mg 60 vcaps
Acetyl-L-Carnitine 250 mg 60 vcaps
SKU: PURE230
Acetyl-L-Carnitine 250 mg 60 vcaps  | Pure Encapsulations - Acetyl-l-Carnitine is a component of the carnitine family (read more)

Acetyl-L-Carnitine 250 mg 60 vcaps  | Pure Encapsulations - Acetyl-l-Carnitine is a component of the carnitine family formed by the acetylation of the amino acid carnitine. It promotes the function of nerve system cells by sustaining cellular energy metabolism in the mitochondria, and ensuring cellular membrane stability*

(hide)
$33.30
Acetyl-L-Carnitine 500 mg 60 vcaps
Acetyl-L-Carnitine 500 mg 60 vcaps
SKU: PURE231
Acetyl-L-Carnitine 500 mg 60 vcaps  | Pure Encapsulations - Acetyl-l-Carnitine is a component of the carnitine family (read more)

Acetyl-L-Carnitine 500 mg 60 vcaps  | Pure Encapsulations - Acetyl-l-Carnitine is a component of the carnitine family formed by the acetylation of the amino acid carnitine. It promotes the function of nerve system cells by sustaining cellular energy metabolism in the mitochondria, and ensuring cellular membrane stability.*

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$59.70
Activated B-12 Guard
Activated B-12 Guard
SKU: PERQ002
Activated B-12 Guard - PERQUE Activated B-12 Guard is in lozenge form for maximum uptake and optimal delivery to the brain. Studies (read more)

Activated B-12 Guard - PERQUE Activated B-12 Guard is in lozenge form for maximum uptake and optimal delivery to the brain. Studies on PERQUE Activated B-12 Guard lozenge formulation show nearly the same B-12 uptake as from injection. B-12 (hydroxocobalamin) 2,000 mcg*

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$39.60
Market price: $45.22 save 12%
Active B Complex 60 vcaps
Active B Complex 60 vcaps
SKU: GENT055
Active B Complex 60 vcaps | Genestra - Co-enzymatic vitamin B’s: The body’s natural active form for energy (read more)

Active B Complex 60 vcaps | Genestra - Co-enzymatic vitamin B’s: The body’s natural active form for energy production and metabolism.*

(hide)
$41.30
Active B-Complex 60 vcaps
Active B-Complex 60 vcaps
SKU: INT076
Active B-Complex 60 vcaps | Integrative Therapeutics - Contains Quatrefolic® brand L-Methylfolate, the bioactive (read more)

Active B-Complex 60 vcaps | Integrative Therapeutics - Contains Quatrefolic® brand L-Methylfolate, the bioactive form of folate- Supports healthy methylation.*

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$18.20
Active Bio-B - 60 caps
Active Bio-B - 60 caps
SKU: EURP014
Active Bio-B - 60 caps | Euromedica - Biologically Active Forms of Vitamin B12 – Folate – B6. Vitamin (read more)

Active Bio-B - 60 caps | Euromedica - Biologically Active Forms of Vitamin B12 – Folate – B6. Vitamin B12 (as methylcobalamin) 1,000 mcg.*

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$22.06
Market price: $25.95 save 15%
Active Chew B12 w/L-Methylfolate 60 tabs
Active Chew B12 w/L-Methylfolate 60 tabs
SKU: GENT056
Active Chew B12 w/L-Methylfolate 60 tabs | Genestra - Co-enzymatic vitamin B’s: The body’s natural active (read more)

Active Chew B12 w/L-Methylfolate 60 tabs | Genestra - Co-enzymatic vitamin B’s: The body’s natural active form for energy production and metabolism*

 

(hide)
$26.70
Active Chewable B12 60 tabs
Active Chewable B12 60 tabs
SKU: GENT057
Active Chewable B12 60 tabs | Genestra - Essential vitamin B12 formula in a natural cherry-flavoured chewable. Vitamin (read more)

Active Chewable B12 60 tabs | Genestra - Essential vitamin B12 formula in a natural cherry-flavoured chewable. Vitamin B12 (methylcobalamin) 1000 mcg*

(hide)
$19.80
Active Folate 1000 90 vegcaps
Active Folate 1000 90 vegcaps
SKU: GENT183

Active Folate 1000 90 vegcaps | Genestra - Provides 1000 mcg of folate per day from Metafolin.*

$27.30
Active Folate B12 60 chewable tablets
Active Folate B12 60 chewable tablets
SKU: DIVN039
Active Folate B12 60 chewable tablets | DaVinci Labs - Active Folate B12 Chewable combines the most active, stable, and (read more)

Active Folate B12 60 chewable tablets | DaVinci Labs - Active Folate B12 Chewable combines the most active, stable, and highly bioavailable forms of folic acid (Quatrefolic brand) and vitamin B12 (methylcobalamin).*

(hide)
$26.50
Adenosyl/Hydroxy B12 90 caps
Adenosyl/Hydroxy B12 90 caps
SKU: PURE219
Adenosyl/Hydroxy B12 90 caps  | Pure Encapsulations - Adenosyl/Hydroxy B12 offers a unique blend of vitamin B12, as (read more)

Adenosyl/Hydroxy B12 90 caps  | Pure Encapsulations - Adenosyl/Hydroxy B12 offers a unique blend of vitamin B12, as adenosylcobalamin and hydroxycobalamin.*

(hide)
$21.90
AdreCor with SAMe 30 vcaps
AdreCor with SAMe 30 vcaps
SKU: NS046

AdreCor with SAMe 30 vcaps | NeuroScience - Contains non-glandular ingredients important for adrenal health and mood.*

$66.00
Advanced Methyl Detox Profile
Advanced Methyl Detox Profile
SKU: ALCT007
Advanced Methyl Detox Profile | Cell Science Systems - The Methyl Detox Profile expands on MTHFR genotyping, giving (read more)

Advanced Methyl Detox Profile | Cell Science Systems - The Methyl Detox Profile expands on MTHFR genotyping, giving you a more complete picture of your body’s detoxification abilities*

(hide)
$399.00
B-Complex +10 mg L-Methylfolate 30 caps
B-Complex +10 mg L-Methylfolate 30 caps
SKU: METHP010
B-Complex +10 mg L-Methylfolate 30 caps | MethyPro - Our B-Complex products combine our best-selling phosphorylated B-Complex (read more)

B-Complex +10 mg L-Methylfolate 30 caps | MethyPro - Our B-Complex products combine our best-selling phosphorylated B-Complex with L-methylfolate from Quatrefolic® in varying doses.*

(hide)
$40.50
Market price: $54.00 save 25%
B-Complex +15 mg L-Methylfolate 30 caps
B-Complex +15 mg L-Methylfolate 30 caps
SKU: METHP005
B-Complex +15 mg L-Methylfolate 30 caps | MethyPro - Our B-Complex products combine our best-selling phosphorylated B-Complex (read more)

B-Complex +15 mg L-Methylfolate 30 caps | MethyPro - Our B-Complex products combine our best-selling phosphorylated B-Complex with L-methylfolate from Quatrefolic® in varying doses.*

(hide)
$49.50
Market price: $66.00 save 25%
B-Complex +5 mg L-Methylfolate 30 caps
B-Complex +5 mg L-Methylfolate 30 caps
SKU: METHP011
B-Complex +5 mg L-Methylfolate 30 caps | MethyPro - Our B-Complex products combine our best-selling phosphorylated B-Complex (read more)

B-Complex +5 mg L-Methylfolate 30 caps | MethyPro - Our B-Complex products combine our best-selling phosphorylated B-Complex with L-methylfolate from Quatrefolic® in varying doses.*

(hide)
$31.50
Market price: $42.00 save 25%

Reviews

Black Box II
Black Box II
I bought this particularly for the Ultra binder and the DIM. Nothing works better than this box + cholestyramine for detoxing mold.
Kevin
Oct 26, 2019
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Neo40 Professional Nitric Oxide Booster

Neo40 Professional 60 lozenges

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