Arginine Plus Suppositories - 60 Count

Arginine Plus Suppositories - 60 Count

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Arginine Plus Suppositories - 60 Count | Zetpil

Arginine Plus Suppositories is one of the most important amino acids and offers many benefits to the human body. It has become very popular among those who work out and lift weights. *

Arginine Plus suppositories were specifically formulated to be taken alone or in combination with the lysine suppository for effectiveness in the body's growth hormone levels, a key hormone that declines with age. It is known for boosting metabolism, healing wounds, removing excess ammonia, improving the immune system and has also been used in patients suffering from congestive heart failure or angina because it helps the blood vessel dilate. L-Arginine has also been used for sexual dysfunction for men and women.*



  • Oral arginine stimulates the release of arginase. Arginase decreases the systemic availability of Nitric Oxide (NO) leading to poor vascular health, diabetes complications, and erectile dysfunction.*
  • Research indicates that NO bioavailability is compromised in the aging human heart and vasculature.*


Potential of Zetpil Arginine Plus

  • Arginine is a precursor to Nitric oxide (NO) and its production/bioavailability decreases with age.
  • Nitric Oxide is a powerful protector against vascular “traumas” such as inflammation, plaque build-up and blood clots (thrombosis) which lead to cardiovascular diseases. *
  • Endothelial dysfunction has been implicated in age-associated issues such as memory loss, hypertension, stroke, erectile dysfunction, and renal dysfunction.*
  • Arginine increases blood flow which improves wound healing.*

Arginine Plus Suppositories - 60 Count | Zetpil

Each Zetpil™ Arginine Plus contains the following ingredients: 

LArginine (a proprietary blend of three of the most active forms of this free amino acid)           444mgs

Magnesium          160mgs

B3/Niacinamide    5mgs

B2/Riboflavin        5mgs

Folinic Acid           1.3mgs

**Note: Each Zetpil™ Arginine suppository is the equivalent of 4,000-5,000 mgs of oral Arginine.   

Serving Size: 1 Suppository
Servings Per Container: 60
Dosage and Use: 2 per day. This product can be taken at any time during the day, before retiring, or as directed by a healthcare professional.
Suppository Base: The base is a proprietary combination of plant and fruit butters, vegetable acids, medium chain triglycerides, phospholipids, lecithin, vegetable starches, cellulose, oligosaccharides derivatives, polysaccharides and cycloamylose derivatives.

This product contains an extract from soybeans making it contraindicated in individuals with a known hypersensitivity to phospholipids, sesame seed oils or any of the listed ingredients.

If you choose to use this product as a rectal suppository, it is highly recommended you attempt to clear your bowels prior to inserting it to avoid premature evacuation. To facilitate insertion it is recommended you moisten the product by passing it under a stream of cool water or use a personal lubricant. When used as a suppository, this product requires 15-20 minutes retention to ensure the complete absorption of the bioactive ingredients. This suppository can be inserted in any position. Although not required, if inserted while lying on one’s side, consider remaining in the supine position for 1-3 minutes following insertion. (Always insert flat end of suppository first).


  • Although safe for children, this product should be kept out of the reach of children.
  • Do not use if the suppositories are open or damaged.
  • As with any nutrient if you are pregnant or breastfeeding, seek the advice of a health care provider before using this product.

Individuals that have chosen to take this product as part of a personal nutrient program have overwhelmingly chosen to utilize this product as a rectal suppository or as a vaginal pessary. However, this product can also be taken safely by mouth. If one chooses to take this product orally, then this product may be considered a dietary supplement in accordance with current FDA guidelines.

Disclaimer: These statements have not been evaluated by the FDA. This product is a Federal Food, Drug, and Cosmetic Act compliant combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA. In accordance with FDA regulations, when taken orally, this product may be considered a dietary supplement as defined by section 201(ff) of the Act, 21 U.S.C. § 321(ff).

Also, this product consists ONLY of a combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA. Therefore, this product cannot be considered a drug as defined in section 201(g)(1) of the Act, 21 U.S.C. § 321(g)(1). This product is not intended to affect the structure or function of the body and is not intended for use in the diagnosis, cure, mitigation, treatment or prevention of disease in man. Any nutritional suggestions and research regarding this product are provided for informational purposes only, and are not intended to diagnose, treat, cure or prevent disease nor should any information provided be used as a substitute for sound medical advice

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Why a Suppository?
The difference between an Arginine Suppository and an oral Arginine supplement is so profound there simply is no comparison. Most people take Arginine to increase endothelial NO, and Growth Hormone.
Oral Arginine is actually dangerous.
In fact patient compliance of the high Arginine dosages needed make it difficult to achieve a consistent therapeutic response. However, if the dosages are too high (subjected to inter-individual variability factor) the excessive dosages can actually suppress the eNOS levels by activating a feedback mechanism the body employs to mitigate the excessive formation of NO. This exists since excessive NO levels facilitate formation of the most damaging free radicals known, i.e. the peroxynitrate prooxidant/ free radical.
Previously performed research has demonstrated that the oral Arginine needed may be as high as 11 grams (...not sustainable from a patient compliance perspective) to achieve a pharmocodynamically effective therapeutic level of 1650 mgs needed by the majority of the patient population to raise the endothelial NO. This high dosage is necessary because Arginine undergoes 85% enzymatic degradation by the compound arginase secreted by the enterocytes and hepatocytes when arginine is orally ingested.
This level of enzymatic degradation makes it extremely difficult to achieve therapeutic dosages orally and/or titrate the oral dosage without triggering a counterproductive pro-oxidant/free radical cascade. Note, this cascade can be prevented by the use of an elevated dosage of melatonin 30mgs (Zetpil Deep Penetrating Crème) or 80 mg SR suppository. However it appears to make more sense to use the specially formulated Zetpil rectal Arginine suppositories (2-3) to achieve the therapeutic dosage. The implementation of this mode of delivery effectively bypasses the arginase secreting enterocytes and hepatocytes, as well as first liver metabolism, 2nd metabolism (dependent on the Arginine form utilized) and inherent hepatic regulation of the release of the Arginine stored as a result of first liver metabolism of the Arginine that has escaped arginase enzymatic degradation.
Rectal delivery might not be the most socially acceptable form of delivery, but it is, in my opinion, the only current mode of delivery that can effectively achieve therapeutic dosages prior research has predicted is needed to increase eNOS and NO formation as well as mitigate atherosclerotic formation or vascular xanthomas .
There is approximately 50mgs of Arginine per gram of crude protein...and again only 15 percent of this, actually gets into the liver, and logically only a fraction is released by the liver effect elevation of vascular NO since Arginine also performs other tasks in the body and thus is subject to the bodies inherent predisposition to ration and distribute compounds as needed given the current biochemical environment.
Citrulline has been proposed but it is dependent on normal kidney function as well an efficient conversion of the citrulline to achieve an elevation of arginine stimulated eNOS/NO.
I personally consistently take Arginine and Piceatannol suppositories in the AM given my familial history of heart disease.
How Much Arginine?
Each suppository is the equivalent of actual 4000-5000 mgs of oral Arginine, since 85% to 90% percent of all oral Arginine undergoes enzymatic degradation and neutralization. Therefore only 10-15% survives when taken orally. There are also forms and each contains only a percentage of actual Arginine. Unfortunately over time, the more you take orally the more you suppress tits usage as it is perceived to be excessive and therefore the very pathway you want to enhance to repair blood vessels actually suppressed to the point of creating deficiency of Arginine. Thus is why it is not a drug. Suppository is the ONLY WAY TO take it to get the desired effect.
The suppositories actually contain 500 mg of ELEMENTAL ARGININE. Please understand the difference...every form of Arginine has a % of Arginine bound to another compound to enhance absorption. Arginine comes as Arginine orotate, aspartate, Arginine AKG Arginine HCL....and each has a certain bioactivity...the suppositories cannot be evaluated as to the amount since it would require you to explain the complete problem with taking oral Arginine. Suffice it to say that all oral forms of Arginine in order to even approach being effective would require one to take 15 grams (15,000 mgs) However a overtime this will actually result in deficiency since the body will perceive this as excessive and shut down the pathways where it is need most
  • Disclaimer

*Your results may vary from those listed above.

*These statements have not been evaluated by the Food and Drug Administration.
*This product is not intended to diagnose, treat, cure or prevent any disease.

Since we do not know everything about your medical history and medications, please consult with your health care practitioner before implementing any new protocols and supplements. Do not construe any information listed on this site as a substitute for actual medical advice. The info you receive from us is not intended to replace medical advice by your doctor. Forrest Health, Inc. does not dispense medical advice, prescribe, or diagnose illness. We offer nutritional programs and supplements that support your health. The views and nutritional advice expressed by Forrest Health, Inc. are not intended to be a substitute for conventional medical service. If you have a medical condition, see your physician of choice.