Apigenin – Powdered LIPO Apigenin 90 caps

Apigenin – Powdered LIPO Apigenin 90 caps

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LIPO Apigenin – Powdered Liposomal Apigenin 90 caps | Renue By Science

  • Highly concentrated 35mg liposomal Apigenin per capsule
  • 90 capsules per bottle
  • 3rd party tested for purity and safety

Apigenin is known to offer a range of health benefits, from supporting heart and brain health to promoting healthier skin.

It indirectly boosts NAD+ by decreasing the activity of the CD38 NAD+-consuming pathway, and has been reported to support cardiovascular, brain, and kidney function, and metabolic benefits.



LIPO Apigenin™ is a sustained-released liposomal delivery system that provides superior absorption of Apigenin in easy-to-swallow capsules.

Our process encapsulates and delivers Apigenin intracellularly in its complete form where it can be absorbed and utilized rather than being destroyed in the stomach.

Apigenin is a naturally-occurring bioactive plant polyphenol with antioxidant, anti-inflammatory, antiviral and neuroprotective properties. Increasing Apigenin in the body has been shown to enhance cognition, stimulate the immune system, diminish oxidative stress and improve cellular detoxification.

LIPO Apigenin™ offers advanced support for:

       ▸  Neuroprotection

       ▸  Inflammation

       ▸  Blood glucose metabolism

       ▸  Nervous system function


Apigenin – a powerful new anti-aging and performance enhancing supplement
Apigenin is a naturally-occurring bioactive plant polyphenol with antioxidant, anti-inflammatory, antiviral, and neuroprotective properties. However, recent research has shown that Apigenin also has a powerful, new anti-aging and performance enhancing benefit as well.

How senescent cells affect NAD+ levels
As we age, we accumulate senescent or “zombie” cells, cells that have reached their limit of cell division and would normally be swept away and replaced by younger cells. Instead, these cells hang around and begin to secrete toxins called SASP factors which increase systemic inflammation, one of the hallmarks of aging. The rising levels of inflammation cause an increase in an enzyme called CD38, a big consumer of NAD+, causing systemic NAD+ levels to drop.

“Our data suggest a link between cellular senescence and NAD+ decline in which SASP-mediated upregulation of CD38 can disrupt cellular NAD+ homeostasis.” (1)

Fighting declining levels of NAD+ with Apigenin
Apigenin prevents excessive loss of NAD+ by reducing the amount of circulating CD38, allowing NAD+ stores to remain at higher, more youthful levels.

“In a recent manuscript, we challenged this paradigm and demonstrated that levels and activity of the NADase CD38 increase during aging, and that this enzyme is the main NAD-consuming enzyme responsible for the aging-related NAD+ decline. We showed that the activity of CD38, but not PARP, increases in several tissues during the aging process, and that genetic ablation of CD38 protects against age-related NAD+ decline and, mitochondrial dysfunction.” (2)

Apigenin could raise NAD+ levels, improve mitochondrial function and endurance performance
In a recent 6-week controlled human trial on the effects of NMN on runners, it was found that moderate to high levels of NMN boosted performance.

“Analysis of covariance of the change from baseline over the 6 week treatment showed that the oxygen uptake (VO2), percentages of maximum oxygen uptake (VO2max), power at first ventilatory threshold, and power at second ventilatory threshold increased to a higher degree in the medium and high dosage groups compared with the control group.” (3)

Significantly, other studies have found that lowering CD38 levels (using a CD38 inhibitor called 78c) not only increased NAD+ levels but also improved mitochondrial function and endurance performance.

“Deletion of PARP-1 or CD38, or the inhibitor of CD38 or PARP-1, improves mitochondrial function and endurance performance in mice.” (4)

“Thus, we tested the effect of 78c on metabolic parameters in mice at different ages. As expected, aged mice (2 years old) had lower tissue NAD+ levels, and worse glucose tolerance compared with younger mice. 78c promoted a significant increase in NAD+ levels in tissues of aged mice but had a negligible effect on NAD+ levels of young mice (3 months old).” (4)


Liposomal Apigenin Encapsulation Efficiency 98%
The aim of this study was to encapsulate apigenin with liposome in an aqueous solution to form small stable particles. The experimental results conclusively demonstrated that it was feasible to decrease the average size of liposome by increasing the sonication time and amplitude; which can have an impact on the cellular uptake of apigenin. Electrophoretic mobility analysis showed that the liposome structure and the stability of the apigenin were maintained during the sonication process. In addition, the liposomes displayed remarkable encapsulation efficiencies (more than 92%), indicating that this technique is suitable to generate a final product rich in apigenin without using organic solvents. The proposed sonication treatment technique, therefore, has a high potential for encapsulation of apigenin for nutraceutical formulations.

Enhanced Efficacy of Apigenin Liposomes
A recent study focusing on establishing apigenin as a potential chemotherapeutic agent for alleviating colorectal cancer reports the development of a stable liposomal nanocarrier with high encapsulation of the hydrophobic flavone apigenin for enhanced chemotherapeutic effects.

“Apigenin liposomes bypass the hurdles posed by apigenin as a chemotherapeutic due to its high hydrophobicity. The enhanced pharmacological activity of apigenin has been assigned to its ability to interact and subsequently influence membrane properties which also resulted in optimal yield of a stable, rigidified, non-leaky nano-carrier with ideal release kinetics.

LIPO Apigenin – Powdered Liposomal Apigenin 90 caps | Renue By Science

  • Highly concentrated 35mg liposomal Apigenin per capsule
  • 90 capsules per bottle
  • 3rd party tested for purity and safety

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*Your results may vary from those listed above.

*These statements have not been evaluated by the Food and Drug Administration.
*This product is not intended to diagnose, treat, cure or prevent any disease.

Since we do not know everything about your medical history and medications, please consult with your health care practitioner before implementing any new protocols and supplements. Do not construe any information listed on this site as a substitute for actual medical advice. The info you receive from us is not intended to replace medical advice by your doctor. Forrest Health, Inc. does not dispense medical advice, prescribe, or diagnose illness. We offer nutritional programs and supplements that support your health. The views and nutritional advice expressed by Forrest Health, Inc. are not intended to be a substitute for conventional medical service. If you have a medical condition, see your physician of choice.