Bromantane Powder 10 g

Bromantane Powder 10 g
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ULAB001
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2 item(s)
Modified
4/23
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10 grams
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ULABS
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$100.99
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$85.84
 
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Bromantane Powder | Umbrella Labs

✓ Dopamine upregulating nootropic

✓ High quality reference material

✓ Contains 180 sprays per bottle

✓ Approximately 9mg per spray

✓ Estimated 90 days of research supply

The psychostimulant effects of bromantane onset gradually within 1.5- to 2-hours and last for 8- to 12-hours

Pharmacology
Bromantane’s mechanism is thought to be like that of Amantadine’s: Kir2.1 potassium channel inhibition. Similarity is shared not only in pharmacology, but chemical structure, as both are adamantane derivatives.
High dopamine biasedly enforces synaptogenesis in D1-containing direct medium spiny neurons, and this creates an imbalance with D2-containing indirect medium spiny neurons. Kir2.1 potassium channel inhibition, however, corrects this, therefore improving disorders such as dyskinesia, psychosis and other detriments caused by abnormally high dopamine.


The anti-inflammatory effects of these compounds indirectly inhibit histone deacetylases, and this gives rise to neurotrophins such as BDNF and especially GDNF. As seen in Parkinson’s patients, GDNF injections had benefits lasting up to 3 years after stopping, maybe explaining Bromantane’s dopaminergic effect which lasts for 2 months after discontinuation. Reduced neuroinflammation and increased neurotrophins also functions as a dual protective measure against neurotoxicity in dopamine neurons.


Bromantane’s benefit to athletic ability may be multifaceted: it may draw influence from the central nervous system as described above, but it may also be secondary to testosterone and/ or tissue oxygenation. Like Bemethyl (Metaprot), Bromantane is in a class of compounds called “actoprotectors”, primarily known for their antihypoxic effects. And like Bemethyl, both are antioxidants, which is believed to underlie these effects (albeit Bromantane a stronger antioxidant). This could be how Bromantane improves testosterone, although the marked reduction to cortisol could also play a role. This combined with the increase in GABA is likely what gives Bromantane an anxiolytic effect.

Pharmacokinetics
Bromantane’s is mistakenly publicized as having a 42% oral bioavailability, however its absolute bioavailability is only 27.5%. Additionally its elimination constant is nearly 60 times higher given orally than intravenously, which could be explained by its accumulation and therefore saturation of the liver which excretes it in the form of oxidized metabolites. This means that other routes of administration, such as intranasal or intravenous, could not only multiply its total absorption, but drastically increase its half life which may be necessary for some effects demonstrated in rodent models.

Bromantane is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. 

 

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*These statements have not been evaluated by the Food and Drug Administration.
*This product is not intended to diagnose, treat, cure or prevent any disease.

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