SAM-e Plus

SAM-e Plus | Karuna - Enterically coated tablets with methylation and transulfuration co-factors

Over a decade of rigorous clinical studies in Europe and elsewhere have established SAM-e (S-adenosyl-L-methionine, an essential methylation and transulfuration cofactor) as a useful tool for supporting normal mood regulation, and joint and liver health.

SAM-e increases cell membrane fluidity, up-regulates neurotransmitter receptor number, and enhances neurotransmitter receptor affinity.

SAM-e supports healthy joints both by increasing the number of articular chondrocytes, and by stimulating the synthesis of protective sulfated proteoglycans therein. SAM-e also protects synovial cells against pro-inflammatory prostanoids, and blocks enzymes that degrade cartilage. SAM-e is a precursor of the critical antioxidant glutathione, a key molecule in the detoxification process in the liver. SAM-e Plus contains the tosylate form of SAM-e as used extensively in clinical trials, and includes several other ingredients found in studies to support and facilitate these functions.

SAM-e Plus tablets are enterically coated, essential for preventing demethylation in the stomach.

S-Adenosyl-L-Methionine (SAM-e) supports normal liver function by acting as a methyl donor, and by promoting the regeneration of sulfur-containing amino acids and glutathione which protect against oxidative stress and toxic substances (Aliment Pharmacol Ther 1993 Feb;7(1):21-8).

SAM-e promotes the health of joints by stimulating the synthesis of proteoglycans in articular chondrocytes; SAM-e acts with minimal or no side effects on the gastrointestinal tract and other organs (Am J Med 1987 Nov 20;83(5A):60-5).

SAM-e is a major source of methyl groups in the brain, and promotes normal brain function in subjects with mood irregularities (Acta Neurol Scand Suppl 1994;154:7-14).

SAM-e Plus tablets are enterically coated, which is essential since oral SAM-e is largely demethylated in the stomach, thereby losing much of its unique character.

SAM-e Plus includes additional nutrient factors essential for normal methylation functions (Proc Nutr Soc 1999;58:441-8, Am J Clin Nutr 1995;61:659S-665S).