Porphyrins Profile
The Biomarkers of Toxicity
Metametrix introduces the Porphyrins Profile! Porphyrins measured in urine serve as biomarkers of toxic effects on the heme biosynthetic pathway. Heme is an essential for the proper function of many
proteins for oxygen transport, energy production, and detoxification. Patterns of specific porphyrin elevations in urine may serve as functional markers to specific toxins, including toxic metals,
such as mercury. The Porphyrins Profile measures seven porphyrins, total porphyrins, and three ratios to help you differentiate heavy metal toxicity in your patient!
Elevations of the individual porphyrin species can have a number of causes, including heredity and environmental contact. Chronic exposure to toxic metals, including lead, mercury, arsenic, aluminum,
and cadmium often results in organ-specific accumulation that compromises target organ physiological function. Heavy metals impair many aspects of metabolism, while chronic exposure to organic
chemicals, such as pesticides, can have deleterious effects on the body’s biochemistry and adversely affect cellular function.
Other causes and conditions related to porphyria include:
Genetic Disorders
Heredity hyperbilirubinemias
Heredity tyrosinemia
Bronze baby syndrome
Erythrohepatic protoporphyria
Metabolic Disturbances
Diabetes mellitus
Myocardial infarction
Hematologic diseases
Disturbance of iron metabolism
Diseases
Infectious diseases
Liver disease
Malignancies
Other Conditions
Pregnancy
Carbohydrate fasting
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