Lipotrienols RYR - 60 vcaps

Lipotrienols RYR - 60 vcaps | Designs for Health
A powerful combination of natural substances intended to support normal blood lipid levels and optimize cardiac and vascular health, including

• High delta-fraction tocotrienols – shown to have an ability to suppress the activity of HMG-CoA reductase.
• Certified organic red yeast rice extract – rich in monocolins known for their effect on modulating blood lipids.
• Lycopene – shown in studies to reduce low density lipoprotein (LDL) oxidation
• Lecithin  - enhances absorption of these fat soluble compounds

Red yeast rice is the product of yeast (Monascus purpureus) containing several compounds collectively known as monacolins, substances known to support normal blood lipid levels. One of these, "monacolin K," is a potent inhibitor of the HMG-CoA reductase enzyme.

Of great importance - The red yeast rice in Lipotrienols RYR™ is USDA certified organic and grown in the USA. Designs for Health takes great care to assay our red yeast rice to assure that there are undetectable levels of citrinin (< 1 ppm), as well as substantial levels of naturally-occurring monocolin compounds (4 mg per 2 capsule serving).

Tocotrienols
Research by Bristol Myers Squibb, and others, has demonstrated that delta and gamma tocotrienols are the most effective
tocotrienol fractions at modulating blood lipids, especially in the absence of tocopherols.9Tocotrienols are often supplied from
rice bran oil or palm oil. These contain between 30-50% tocopherols. Tocopherols greater than 20% decrease the effect of
tocotrienols on modulating blood lipids.  Annatto tocotrienols, used in Lipotrienols RYRTM, are a unique makeup of 90%
delta-tocotrienol and 10% gamma-tocotrienol with zero tocopherols. Research has clearly proven the ability of tocotrienols to
modulate blood lipids.10Tocotrienols decrease the conversion of farnesyl, a mevalonate derived intermediate, to farnesol, which
usually goes on to make squalene and ultimately cholesterol. The increasing farnesol pool then signals the proteolytic degradation
and downregulation of the HMG-CoA reductase enzyme. Tocotrienols also upregulate LDL receptors and LDL clearance and also
inhibit the progressionof carotid artery stenosis that may lead to stroke.9-10

Profound synergism has been demonstrated in the peer-reviewed literature regarding the concomitant use of both lovastatin and
tocotrienols in favorably altering serum lipid profiles and reducing biomarkers of cardiovascular risk.11-12 For example, a 14%
reduction in total cholesterol was seen when used alone vs. a 20% reduction when taken together.13Since red yeast rice is also
a HMG-CoA reductase inhibitor it is likely that similar synergistic effects between red yeast rice and tocotrienols would also be
observed.

Lycopene
Lycopene is a carotenoid present in human serum, liver, adrenal glands, lungs, prostate, colon, and skin at higher levels than
other carotenoids. Lycopene has been found to possess antioxidant and antiproliferative properties  in animal and in vitro stud-
ies. Numerous epidemiological investigations have correlated high intake of lycopene-containing foods or high lycopene serum

Tocotrienols
Research by Bristol Myers Squibb, and others, has demonstrated that delta and gamma tocotrienols are the most effective
tocotrienol fractions at modulating blood lipids, especially in the absence of tocopherols.9Tocotrienols are often supplied from
rice bran oil or palm oil. These contain between 30-50% tocopherols. Tocopherols greater than 20% decrease the effect of
tocotrienols on modulating blood lipids.  Annatto tocotrienols, used in Lipotrienols RYRTM, are a unique makeup of 90%
delta-tocotrienol and 10% gamma-tocotrienol with zero tocopherols. Research has clearly proven the ability of tocotrienols to
modulate blood lipids.10Tocotrienols decrease the conversion of farnesyl, a mevalonate derived intermediate, to farnesol, which
usually goes on to make squalene and ultimately cholesterol. The increasing farnesol pool then signals the proteolytic degradation
and downregulation of the HMG-CoA reductase enzyme. Tocotrienols also upregulate LDL receptors and LDL clearance and also
inhibit the progressionof carotid artery stenosis that may lead to stroke.9-10

Profound synergism has been demonstrated in the peer-reviewed literature regarding the concomitant use of both lovastatin and
tocotrienols in favorably altering serum lipid profiles and reducing biomarkers of cardiovascular risk.11-12 For example, a 14%
reduction in total cholesterol was seen when used alone vs. a 20% reduction when taken together.13Since red yeast rice is also
a HMG-CoA reductase inhibitor it is likely that similar synergistic effects between red yeast rice and tocotrienols would also be
observed.

Lycopene
Lycopene is a carotenoid present in human serum, liver, adrenal glands, lungs, prostate, colon, and skin at higher levels than
other carotenoids. Lycopene has been found to possess antioxidant and antiproliferative properties  in animal and in vitro stud-
ies. Numerous epidemiological investigations have correlated high intake of lycopene-containing foods or high lycopene serum levels with reduced incidence of cancer, cardiovascular disease, and maculardegeneration.14-16A group of researchers gave post-
menopausal women either HRT (hormone replacement therapy) or 2 mg lycopene. Both gave similar significant reductions in
total cholesterol and LDL and an increase in HDL.17 Women who do not wish to use HRT during menopause can receive the
same protection from coronary artery disease by consuming lycopene. 

Lecithin
Lecithin (40% phoshatidylcholine) has been shown in research to enhance absorption of lycopene and likely aids absorption of
the other fat-soluble compounds such as the tocotrienols.18

How to Take Lipotrienols RYRTM
Dosage: As a dietary supplement, take two capsules with food, at night, since cholesterol synthesis is greatest while sleeping.
Take a few hours away from an alpha-tocopherol, vitamin E, containing product such as a multivitamin.

Should Anything Else Be Taken with Lipotrienols RYRTM?
Since Lipotrienols RYRTMaffects the HMG-CoA-reductase enzyme, although more subtly than statin medications, it may
mildly reduce endogenous production of coenzyme Q10. Therefore, it is advised that those taking Lipotrienols RYRTMalso
take supplemental CoQ10, such as Q•Avail or Q•Avail Nano by Designs for Health.

For even more aggressive lipid control consider DFH Cholesterol Support Packets.

Who Should Not Take Lipotrienols RYRTM
This product is not recommended for pregnant and lactating women. Cholesterol levels naturally increase during pregnancy to
support the necessary increase in hormone production.