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KPU/HPU Test

KPU/HPU Test
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HPU/KPU Test | Health Diagnostics

Lyme Disease Screening Test

Kryptopyrrol in urine - The test measures the porphyrin derivative kryptopyrrol (Mauve factor) in urine. Kryptopyrrol is a porphyrin derivative. Porphyrins are cyclic compounds that readily bind metal ions. They constitute haeme-proteins, including haemoglobin, myoglobin and cytochrome P450. Inherited or occasionally acquired defect in haeme-synthesis can result in accumulation and increased excretion of porphyrins or porphyrin precursors. Clinical manifestations may be neurovisceral and/or cutaneous. 


The condition of pyrroluria is associated with a deficiency of vitamin B6 (pyridoxine) and zinc.
- Anorexia
- Anemia that does not repond to iron
- Alcoholism
- Autonomic dysfunction
- Chemical exposure
- Cutaneous photosensitivity
- Hyperactivity
- Heavy metal poisoning (lead)
- Menstrual irregularities
- Neuropsychiatric symptoms
- Schizophrenia 
- Stress (prolonged)
- Malformation of knee cartilage along with joint pains 
- Abdominal pain 

KPU is a frequent co-factor in patients with: 1) heavy metal toxicity (detox pathways are overwhelmed and ineffective, lack of glutathione); 2) Lyme disease (microbes induce KPU enzymes to deplete white cells of zinc and weaken their fighting abilities); 3) Many -if not most neurological illnesses (common in MS, Parkinson, Depression, Autism). When KPU is correctly diagnosed and the recommended substitution of supplements is included in the treatment of any chronic illness, outcome can be dramatically improved.Dietrich Klinghardt, M.D., PhD.

"When the methylation cycle is restored, the normal detox system deals with more of the toxins.Dietrich Klinghardt, M.D., PhD

We recommend the Kryptopyrrole (KPU) Test on an individual basis where needed in order to assess the methylation detox pathways.


For more information contact Forrest Health at 408.354-4262


HPU/KPU Protocol for Lyme and Autism developed by: Dietrich Klinghardt, M.D.
Dr. Dietrich Klinghardt is a physician specializing in neurological diseases such as autism and lyme, practicing out of Kirkland, Washington. Over the years, he has found that the lyme and autism patients who did not progress in their recovery many times had an underlying condition known as hemopyrrollactamuria (HPU), also known as kyptopyrroluria (KPU). HPU is a severe but reversible deficiency of zinc, biotin, manganese, vitamin B6 (or P5P), and arachidonic acid. When treated for this condition, his patients were then able to move forward in their treatment with success.

Dr. Klinghardt has found that HPU occurs in Lyme disease around 80% of the time (or more), and it occurs in over 75% of patients with heavy metal poisoning. The incidence of HPU in children with autism is over 80%.


What Is It?
HPU is an abnormality in heme synthesis. Hemoglobin is the substance the holds iron in the red blood cells. Hydroxy-hemopyrrolin-2-one (HPL) is a byproduct of hemoglobin (heme) synthesis and can be identified in the urine. HPLs bind to zinc, biotin, manganese, vitamin B6, arachidonic acid and other vitamins and minerals and lead to a significant depletion of these compounds in the brain and body.


Potential symptoms
DigitalNaturopath.com says many symptoms can result, including severe inner tension, ongoing anxiety, poor stress control, fearfulness, and sometimes episodic anger.

Often such people have pale skin that easily burns, eyes that are sensitive to light, white flecks/marks on their nails, and stretch marks on their skin. They tire easily, are anemic, have poor dream recall, prefer not to eat breakfast, notice upper abdominal pain when stressed, and experience a stitchin their side if they run. They have a tendency to become loners as they age. Mental symptoms are aggravated when undergoing stress. In fact, pyroluria flares up when the individual is undergoing prolonged stress, such as during a chronic and debilitating illness.

Pyroluria may occur along with other imbalances as seen in some subtypes of schizophrenia such as histapenia (low histamine), histadelia (high histamine), high copper levels or cerebral allergies. It is the primary imbalance for 20% of schizophrenics.

Alcohol use is one way for pyrolurics to shut off their anxiety, feel more sociable, de-stress, and experience a short time when they feel more normal. Without a knowledge of this chemical imbalance, those who try to quit alcohol use must face coexisting with their symptoms. If additional antianxiety support is needed, GABA, tryptophan, chromium and inositol should be considered.1


How does one get tested/diagnosed?
Scott Forsgren writes in his Public Health Alert (May 2010) article Kryptopyrroluria (aka Hemopyrrollactamuria): A Major Piece of the Puzzle in Overcoming Chronic Lyme Disease, that HPL levels can be measured from urine through the laboratory lab.

Vitamin Diagnostics offers a test for the related compound called kryptopyrrol only. Recently, they began to offer a test for the hydroxy-hemopyrrolin-2-one (HPL) compound. When filling out the requisition, the practitioner can now select HPL in addition to kryptopyrrol. The HPL test results in a much higher yield.

Dr. Klinghardt finds that in order to get the best possible insight into the patients condition, it is best to avoid all supplements, especially those containing zinc, biotin, and vitamin B6, for 5-7 days before the urine sample is collected. He suggests that patients use a 24-hour urine collection as opposed to first morning urine as the release of HPL complex into urine is not consistent and might be missed in a single urine collection. The sample should be shielded from light. 500mg ascorbic acid should be added to each liter of urine as a preservative.

To further maximize the benefit of testing for the condition, it is best for the patient to be under stress at the time the test is being performed as HPL excretion is known to increase during times of stress.

Dr. Klinghardt has found that Vitamin Diagnostics has the best test for HPU available in the United States. In some circumstances, however, patients may still test negative even when the condition is suspected. In those cases, an empiric trial of the HPU protocol may still be warranted.

Other laboratory results that may be suggestive of HPU include:

  • WBC < 5000/mcL (due to low levels of zinc)
  • High LDL / Low HDL
  • Low normal alkaline phosphatase (<60U/L)
  • Low omega-6 fatty acids in red cell membrane test
  • Low taurine in amino acid profile
  • High MCV
  • WBC and RBC zinc and manganese levels may be normal while biopsies from bone and CNS are completely deficient

Bone biopsies are a reliable predictor of HPU. Severe deficiencies of zinc, manganese, lithium, calcium, magnesium, and molybdenum are often found."2

Additional information
Product label

 HPU/KPU Test | Health Diagnostics

Sample: Urine

Test fees include: test kit, mailer, test instructions, processing, handling, shipping, test results/reports and review.

Consultations with Dr. Forrest are available by appointment:  Consultation information

 

Disclaimer:  The statements enclosed herein have not been evaluated by the Food and Drug Administration. The ordering of tests from this site does not imply a doctor patient relationship. They are informational and educational only. Forrest Health, Inc. does not dispense medical advice, prescribe or diagnose illness. We offer nutritional programs and supplements that allow the body to rebuild and heal itself.

The products and information mentioned on our website are not intended to diagnose, treat, cure, or prevent any disease. Information and statements made are for education purposes and are not intended to replace the advice of your treating doctor. Dr. Forrest is licensed as a Chiropractor in the state of California since 1987. He is not a medical doctor and as such cannot comment on your use of prescription medicines or other controlled substances.

For your health and safety please consult with your health care practitioner before implementing any new protocols and supplements. Do not construe any information listed on this site as a substitute for real medical advice. The views and nutritional advice expressed by Forrest Health, Inc. are not intended to be a substitute for conventional medical service. It is generally recommended that you do not self diagnose and treat. If you have a medical condition, see your physician of choice.

Forrest Health, Inc. does not provide insurance billing for anything purchased through this site. We do not provide diagnosis or insurance billing codes. If this is important to you we recommend working with your local physician who can provide such services.

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Disclaimer: The statements enclosed herein have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease

Since we do not know everything about your medical history and medications, please consult with your health care practitioner before implementing any new protocols and supplements. Do not construe any information listed on this site as a substitute for actual medical advice. The info you receive from us is not intended to replace medical advice by your doctor. Forrest Health, Inc. does not dispense medical advice, prescribe, or diagnose illness. We offer nutritional programs and supplements that support your health. The views and nutritional advice expressed by Forrest Health, Inc. are not intended to be a substitute for conventional medical service. If you have a medical condition, see your physician of choice