ABOUT NITRIC OXIDE Is it possible to have too much Nitric Oxide? Yes. Too much Nitric Oxide is associated with headaches, dizziness and low blood pressure. However, Neo40Â® Daily is a proprietary blend that supplies the essential nutrients and building blocks necessary for the body to naturally produce its own Nitric Oxide and restore healthy levels for each individual. Two lozenges is roughly the equivalent of eating a spinach salad when you were younger and your body was able to create its own Nitric Oxide. Can Nitric Oxide restoration help with diabetes or high blood pressure? Although we do not have clinical trials to demonstrate effect on blood pressure or diabetes, we know that Nitric Oxide insufficiency is responsible for high blood pressure and many complications of diabetes. When should I ask my doctor about Nitric Oxide? As with any nutritional supplement, check with your pharmacist or physician when adding to your regimen. However, many practitioners are just now learning the benefits of Nitric Oxide and about products like Neo40 Daily designed to help restore levels. There are resources on the Neogenis website dedicated to informing the medical community about the latest research. What foods can I eat to increase my Nitric Oxide production? Many foods are rich in Nitric Oxide, such as spinach, nuts, artichokes, beets and certain green teas. Lifestyle modifications including exercise, deep breathing and healthy diet are the best ways to enhance Nitric Oxide production. However, it gets harder to consume enough of these foods in order to compensate for the declining production levels of your body as you age. Isn't Nitric Oxide the active ingredient in nitroglycerine? Yes, but not in the explosive sense. Nitric Oxide is an active ingredient in nitroglycerine, which has been used for centuries as a treatment for acute angina. Because Nitric Oxide is a vaso-dilator, it can, in large doses, quickly enhance blood flow during a cardiac emergency. The levels used in these situations are hundreds of times greater than what you would receive in a Nitric Oxide-enhancing supplement like Neo40Â® Daily. Are certain ethnic groups more prone to insufficient Nitric Oxide levels? Yes, African-American populations have been shown to naturally produce less Nitric Oxide levels that any other ethnicity. Why have I never heard of Nitric Oxide before? Discovered as a signaling molecule in 1988, Nitric Oxide, commonly referred to as NO, is a gas that consists of one nitrogen atom and one oxygen atom. It is one of the most important signaling molecules in the human body, because it's a vaso-dilator, "telling" arteries and veins to relax, thus improving circulation. In 1992 Nitric Oxide was proclaimed the "Molecule of the Year" by the American scientific community. Nitric Oxide helps maintain normal blood pressure, heart function, helps fight infections and is a main regulator of brain and digestive function. Previously, this information has only been available to the scientific community through over 100,000 published research papers and over 200 government Nitric Oxide clinical trials currently underway. The discovery of the critical role Nitric Oxide plays in the human body was awarded a Nobel Prize in 1998, but it has taken until now to discover a way to effectively increase production of Nitric Oxide in our bodies for cardiovascular health. Most people who have heard of Nitric Oxide know it from bodybuilding, workout or erectile dysfunction supplements. IS NEO40 DAILY SAFE TO TAKE WITH...? Can I take Neo40Â® Daily with my prescription drugs? Ask your doctor or pharmacist. It is always important to seek medical advice before adding supplements to your regimen if you are currently taking prescription drugs. However, many medical professionals are just now learning the benefits of Nitric Oxide and becoming aware of products that help restore levels. There are resources on the NeogenisÂ® Labs website dedicated to informing the medical community about the latest research. What if I have heart problems? As with any nutritional supplement, check with your pharmacist or physician when adding to your regimen. Low Nitric Oxide production is responsible for many cardiovascular problems. Nitric Oxide naturally dilates blood vessels, thereby improving blood flow and maintaining a healthy cardiovascular system. Do I still need to take my prescription drugs if I am taking Neo40Â® Daily? Always consult your physician or pharmacist before discontinuing any prescription drugs. What if I'm already taking Viagra or another erectile dysfunction drug? As with any nutritional supplement check with your physician or pharmacist when adding to your regimen. Erections are due to an increase in blood flow into the corpus cavernosum of the penis in men and clitoral engorgement due to increased blood flow in women. This increased blood flow is facilitated by the production of Nitric Oxide. Without sufficient Nitric Oxide production there is reduced blood flow and erectile dysfunction (ED) or the inability to produce and sustain an erection. Erectile dysfunction is classified as a vascular problem and is the direct result of insufficient Nitric Oxide production in the body. Current ED medications such as Viagra and Cialis work through a Nitric Oxide pathway. So without Nitric Oxide, these medications are ineffective. What if I'm already taking cholesterol medication, like Crestor? As with any nutritional supplement check with your physician or pharmacist when adding to your regimen. Neo40Â® Daily is made of botanicals and other ingredients that help your body naturally produce Nitric Oxide. Can I take Neo40Â® Daily with other supplements? As with any nutritional supplement check with your physician or pharmacist when adding to your regimen. But because Neo40 Daily supports healthy circulation it could actually enhance the delivery and absorption of other nutrients, medications and supplements. Do I still need my other vitamins? Most likely, but this should be discussed with your healthcare practitioner. Neo40Â® Daily supports healthy circulation so it could actually enhance absorption of your other vitamins. DOSAGE & WHAT TO EXPECT Should I take one or two a day? Every person's body chemistry is somewhat different, so we recommend that you start by taking Neo40Â® Daily twice per day, testing your Nitric Oxide level frequently. NeogenisÂ® Test Strips are the first and only non-invasive test for Nitric Oxide levels. When you are able to maintain a "normal" reading over a period of several days you may reduce your dose to one per day and continue testing to confirm you can sustain your level. My Neo40 Daily fast-melt lozenges seem to be turning slightly brown. Is this normal? Like many natural supplements, Neo40 Daily is EXTREMELY sensitive to heat and humidity. Make sure you store your Neo40 Daily in a cool, dry environment. However, the change in color will not impact effectiveness of the product and you may continue to use it. How will Neo40 Daily make me feel? Because Nitric Oxide improves circulation, most people feel a greater sense of well-being and a boost in energy. We have heard many Neo40 Daily stories, that people feel more alert, more relaxed, that they have improved mood, sustained energy levels and better quality sleep. How will I know itâ€™s working? Use NeogenisÂ® Test Strips to track your Nitric Oxide restoration progress. You may also notice an increase in energy, better sleep patterns and enhanced mental acuity. How long will it take to see results? This varies by person. Some people feel better immediately, some in as little as three days, while others report that it takes longer. The length of time it takes to replete your Nitric Oxide levels and sustain them varies dramatically. Though not often the case, if you have a persistent, chronic health issue it is possible that restoring satisfactory levels can take months or even a year. It makes me feel a little burpy. Is that normal? Yes, it can be for some. Nitric Oxide is a gas. Neo40Â® Daily is helping your body produce it naturally, which can create excess gas initially. For those who do experience this effect it is usually mild. In fact, most people who experience any burping at all only experience one mild burp shortly after the lozenge has dissolved. My tongue feels sensitive after the Neo40Â® Daily dissolves. Is that OK? Yes. This is not unusual, especially if you are taking Neo40 Daily twice a day. We recommend that you move the lozenge across your tongue and around in your mouth as it dissolves. If you still experience some tenderness, you can chew the lozenge for faster absorption. Will Neo40Â® Daily keep me awake at night? No, quite the contrary. Nitric Oxide often helps promote sleep because of its vasodilatation (relaxing) function. However, since there are B Vitamins in Neo40 Daily, if you experience sleeplessness take it earlier in the evening. But if you're taking Neo40 Daily twice/day, be sure your two doses are still 12 hours apart. What is Neo40 Daily made of? Neo40 Daily is a proprietary, patent-pending combination of natural products and functional foods that have been scientifically proven to help the body naturally produce Nitric Oxide. NITRIC OXIDE AND WORKOUTS How can Neo40 Daily help with my workouts? Neo40 Daily, although designed the restore Nitric Oxide production for overall circulation support, is very effective as a pre-workout product. In fact, our tests comparing to a leading L-arginine-based workout supplement, showed that Neo40 Daily facilitated significantly more Nitric Oxide output. Neo40 Daily is designed to enhance Nitric Oxide cellular production, creating a system for production when oxygen is limited as it is during workouts. Additionally, we have preliminary data indicating that taking our product before sub-maximal exercise leads to less lactic acid production in the blood and therefore better recovery after workout. Do all Nitric Oxide-generating products contain L-arginine? L-arginine is a semi-essential amino acid used for Nitric Oxide production. It is found in many bodybuilding supplements on the market today. However, clinical trials have shown that in patients with heart conditions, at risk for heart attack or over 40 years old, L-arginine can actually do more harm than good. Neo40Â® Daily does not contain L-arginine and employs a different mechanism for generating Nitric Oxide in the body that is not contingent on health level or age. NEOGENIS TEST STRIPS What exactly is measured by the NeogenisÂ® Test Strips? We know that once Nitric Oxide is produced by the endothelial cells or other cells in the body that it is oxidized to nitrite and nitrate. The NeogenisÂ® Test Strips measure the amount of Nitric Oxide that is recirculated through the saliva. This measure represents the total systemic bioavailability of Nitric Oxide because with less Nitric Oxide produced by the vascular cells, there is less concentrated in the saliva. Thus, the test strips are detecting the total amount of Nitric Oxide produced in the body and the amount of Nitric Oxide the body converts from food intake. How often should I test? We recommend testing every day when you first begin taking Neo40Â® Daily. This will help you track your Nitric Oxide restoration process. Iâ€™ve been taking Neo40 Daily for a while and am still testing low. What should I do? Continue to take it! Most people require at least 60-90 days on Neo40 Daily to begin to impact their sustained Nitric Oxide levels. Can I stop taking it when my level stays normal? You can continue to reduce your dose as long as your level stays consistent. However, most adults over 40 are unable to maintain a normal reading without supplementation. Further, as you age your ability to naturally produce Nitric Oxide declines dramatically. Thus, it's likely that your level will not stay normal as you get older.