EstroVantage EM Estrogen Modulator 90 vcaps

EstroVantage EM Estrogen Modulator  90 vcaps
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EstroVantage EM Estrogen Modulator  90 vcaps | Bioclinic Naturals

EstroVantage EM reduces the risks associated with hormone imbalance and supports healthy estrogen metabolism and a healthy estrogen metabolism ratio.

Vitamin D is a hormone now widely recognized to be important to many body systems and a large number of physiological processes, and it may also be one of the most common nutrient deficiencies in the world. Many recent studies have linked lower levels to an increased risk of cardiovascular disease, including hypertension, peripheral vascular disease, coronary artery disease, and heart failure, as well as several types of cancer, autoimmune disease, and type 2 diabetes. Vitamin D is needed for intestinal calcium absorption, skeletal bone integrity as well as skeletal muscle strength and function, and has been associated with overall physical fitness. Vitamin D is critical for healthy immune function, and may reduce the risk of infection, especially respiratory tract infections. Given that essentially every tissue in the body has a receptor for vitamin D, it is hard to overestimate its importance. Many practitioners recommend supplementation to achieve blood levels of 25-OH-vitamin D between 50-80 nmol/L, which often requires doses of 1000-2000 IU per day, and more for those with common genetic variants affecting vitamin D metabolism.

In general, estrogen can be divided into several biochemically distinct hormones: estrone (E1), estradiol (E2), estriol (E3), and 17ß-estradiol.1 In premenopausal women, estrogen is enzymatically converted to several specific estrogen metabolites including 2-hydroxyestrone (2-OHE1), 2-hydroxyestradiol (2-OHE2), 4-hydroxyestrone (4-OHE1), 4-hydroxyestradiol (4-OHE2) and 16a-hydroxyestrone (16a-OHE1). Both 16a-OHE1 and 2-OHE have contrasting biological activities at the cellular level with 16a-OHE1 being an estrogen agonist and proliferative, while 2-OHE is an estrogen antagonist and antiproliferative.2 As such, an increased ratio 2-OHE:16a-OHE1 is associated with a reduced risk of invasive breast cancer risk in premenopausal women.3 Several natural products found in EstroVantage EM support this latter concept including DIM, and indole 3 carbinol (I3C). A human study has confirmed that daily supplementation with 300 mg of I3C daily for 12 weeks significantly increased the 2-OH-estrone: estriol metabolite ratio without notable adverse events.4 Other compounds in EstroVantage EM, including calcium-d-glucarate, inhibit beta-glucoronidase activity, allowing for the excretion of estrogen before reabsorption.5It is estimated that a 4% calcium glucarate supplemented diet inhibits beta-glucuronidase activity by 70%.6
  • IGF-1 has a known pathogenic role in cancer, increasing growth of existing cancer cells. Lycopene supplementation decrease IGF-1 by 25%.7
  • In a 34 patient randomized controlled trial foods enriched with bioactive compounds, including rosemary extract (Rosemarinus officinalis), were found to be a promising adjuvant therapy in advanced breast cancer patients8
  • Green tea polyphenols inhibit the proliferation of breast cancer cells in vivo andin 
  • Silymarin can down-regulate gene products involved in the proliferation of tumor cells (cyclin D1, EGFR, COX-2, TGF-beta, IGF-IR), invasion (MMP-9), angiogenesis (VEGF) and metastasis (adhesion molecules)10
  • Curcumin inhibits human breast cancer cell growth by mediating certain signaling cascades including the modulation of the NF-kB signaling pathway11
  • Sulforaphane can inhibit the expression of estrogen receptor alpha (ERalpha) protein in MCF-7 cells, inhibiting proliferation and down-regulating hormone receptor expression12
  • Standardized extracts
  • In a base of organic flaxseed oil and organic olive oil for improved intestinal absorption
  • Vitamin D(cholecalciferol) likely more effective at restoring blood levels than D2form (ergocalciferol)
  • Neutral taste
  • Preserved with natural vitamin E
  • Liquid form is convenient for a wide range of doses
  • 500 drops per bottle

EstroVantage EM Estrogen Modulator  90 vcaps | Bioclinic Naturals

Serving Size 3 Capsules 
Servings Per Container 30 

Amount Per Serving 
Calcium D-Glucarate (d-glucaric acid calcium salt) ...............................225 mg 
Indole-3-Carbinol (3-hydroxymethylindole) ........................................225 mg  
Green Tea Extract (Camellia sinensis) (leaf) ........................................150 mg  
(80% catechins, 45% EGCg <1% caffeine) 
Tomato Extract (Lycopersicon esculentum) (fruit) (5% lycopene) .......150 mg 
Broccoli Powder (Brassica oleracea var. italica) (aerial) .........................83 mg 
(0.36% sulforaphane) 
Turmeric Extract (Curcuma longa) (root) (95% curcuminoids) ...............75 mg  
Milk Thistle Extract (Silybum marianum) (seed) (60% silymarin) ...........75 mg  
DIM (3,3’-diindolylmethane) .................................................................75 mg 
Rosemary Extract (Rosmarinus officinalis) (leaf) ....................................38 mg 
Other ingredients: Microcrystalline cellulose, vegetarian capsule (carbohydrate gum[cellulose], purified water), magnesium stearate (vegetable grade) and silica.
3 capsules per day taken with food or as directed by a health care professional. Consult a health care professional for use beyond 12 weeks. Keep out of reach of children.
Do not use if you are pregnant or breastfeeding, or if you have iron deficiency. Consult a health care professional prior to use if you have a liver disease or develop symptoms of liver trouble. Hypersensitivity/allergy is known to occur, in which case discontinue use. Consult a health care professional if you have gallstones or a bile duct obstruction, stomach ulcers or excess stomach acids, if you are taking any medication such as antiplatelet medication or blood thinners, or if you are attempting to conceive. Keep out of reach of children.
Do not take with warfarin.13
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Disclaimer: The statements enclosed herein have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease

Since we do not know everything about your medical history and medications, please consult with your health care practitioner before implementing any new protocols and supplements. Do not construe any information listed on this site as a substitute for actual medical advice. The info you receive from us is not intended to replace medical advice by your doctor. Forrest Health, Inc. does not dispense medical advice, prescribe, or diagnose illness. We offer nutritional programs and supplements that support your health. The views and nutritional advice expressed by Forrest Health, Inc. are not intended to be a substitute for conventional medical service. If you have a medical condition, see your physician of choice