Cognitex® with Pregnenolone & NeuroProtection Complex 90 gels
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Cognitex® with Pregnenolone & NeuroProtection Complex 90 gels | Life Extension Foundation
Protecting brain health is vital if the pursuit of a longer life is to have any meaning. According to current wisdom, some degree of cognitive decline is inevitable as we age,1-5 unless we take steps to prevent it.6-9 The ideal strategy for preserving brain function begins with preventing factors that may contribute to cognitive decline. Good nutrition, including dietary supplements, and a healthy lifestyle are key. Keep your blood pressure and weight in check. Then focus on nutritional support.*
Cognitex® is formulated to take advantage of the latest developments and ingredients for cognitive health. One of the unique ingredients in the Cognitex® formula is uridine-5’-monophosphate, a critical brain nutrient.*10
Uridine-5’-monophosphate (UMP) is a basic building block of RNA/DNA as well as of phosphatides such as phosphatidylcholine that are critical to brain function and the health of neuronal cell membranes. Naturally found in the milk of nursing mothers, UMP is essential for the growth and development of infant brains.11 Animal studies suggest that dietary supplementation with UMP may increase brain acetylcholine and phosphatide levels, and enhance some cholinergic functions.*12,13
The Cognitex® formula provides other critical extracts that support healthy brain function, such as wild blueberry standardized to anthocyanins. Anthocyanins, found in blueberries, are considered one of nature’s most potent antioxidants and have demonstrated properties that extend well beyond suppressing free radicals.*14-16
Phosphatidylserine (PS) is a crucial building block in the brain. In fact, brain tissues are especially rich in this nutrient. However, aging causes a decline in the PS content of cells throughout the body including brain cells, which can lead to cognitive decline. Phosphatidylserine helps the brain use its fuel efficiently. By boosting glucose metabolism and stimulating production of acetylcholine, supplemental phosphatidylserine has been shown to improve the condition of patients experiencing age-associated memory impairment or cognitive decline.17,18 Thus, replacing this brain food is essential.*
Cognitex® contains a compound that mimics the naturally occurring PS in the brain. Sharp-PS® GOLD, fortified with omega-3 fatty acids, delivers PS to the brain to help maintain youthful cognitive function. These unique nutrients have been extensively studied and may be of tremendous benefit for the aging brain.*19
The brain is a metabolically active organ that produces high levels of free radicals. These free radicals can bombard the cell membranes of neurons causing premature loss of function. Cognitex® contains a number of phytonutrient-based antioxidants that work best in a lipid (fat) rich environment like the brain.*
While antioxidant nutrients provide essential free radical protection, many have limited capacity once they have spared an electron to balance a free radical. Cognitex® contains a rosemary extract that is rich in carnosic acid, which provides multi-step protection against free radicals in a process called the carnosic acid cascade.20 At each step of free radical interaction a new compound is formed, which in turn is a powerful antioxidant in itself.*
Nutritional support for the brain can be challenging because the "blood-brain barrier" can keep out not only harmful substances but beneficial nutrients and drugs as well. Cognitex® contains a grape seed extract called Leucoselect® Phytosome™. By pairing grape seed polyphenols with phosphatides from soy lecithin in the Phytosome™, the uptake and distribution to target tissues of the grape seed polyphenols is enhanced.*
Once in the brain, the grape seed polyphenols trap dangerous hydroxyl free radicals that turn fat rancid.21 These fats make up the outer lipid membrane of trillions of brain cells. These polyphenols also protect blood circulation and oxygen flow by improving the tone and elasticity of blood vessels.*
High levels of procyanidins from grape seed extract do not ensure an extract is going to have a beneficial effect on the brain. Polyphenols with higher molecular weight cannot be absorbed. Leucoselect® Phytosome™ contains smaller size molecules for advanced neurological activity.*
Taking dietary supplements can seem like an act of faith since we often cannot feel their effects. Cognitex® provides a patented, nonstimulant phytonutrient called Sensoril®. Sensoril® is a proprietary standardized extract of ashwagandha (Withania somnifera), also known as "Indian ginseng,"24-26 which is used in Ayurvedic traditional medicine for boosting brain function and alleviating mental fatigue.27 Advanced extraction practices allow for a highly concentrated yet balanced brain nutrient. The effects can often be felt immediately with greater alertness and focus ... but without jitteriness.*
Stress can be very damaging to the brain, especially memory function. Sensoril® also helps modulate cortisol secretion, which positively influences the stress response.*28
Cognitex® provides a NeuroProtection Complex consisting of concentrated standardized extracts of hops and rosemary that help suppress inflammatory cytokines.*29
In an adult, cerebral blood flow is typically 750 milliliters per minute or 15% of the cardiac output. Vinpocetine enhances cerebral blood flow by dilating blood vessels and reducing blood viscosity. Vinpocetine enhances cerebral metabolism by helping to maintain healthy blood flow and oxygen utilization.*30
L-alpha-glycerylphosphorylcholine (alpha-GPC), a precursor to the neurotransmitter acetylcholine, is naturally present in all the body’s cells.31 A decline in acetylcholine levels coincides with advancing age and is a hallmark of neurodegeneration. Cognitex® provides alpha-GPC as a crucial building block for the production of acetylcholine in the brain. The safety and importance to life of alpha-GPC is evidenced by its substantial presence in human breast milk.32,33 Proper acetylcholine function is essential to muscle control, sleep, and cognition. Alpha-GPC plays a key role in both the synthesis and the catabolic recycling of phospholipids. Alpha-GPC supplementation may result in enhanced phospholipid synthesis, including synthesis of the phosphoinositides available for signal transduction at central nervous system level.*34
Cognitex® is available with pregnenolone. Pregnenolone is a neuroactive hormone that may be especially beneficial to the brain35-46, yet the body’s production of it declines with age.*
Cognitex® with Pregnenolone & NeuroProtection Complex 90 gels | Life Extension Foundation
Cognitex 90 softgels
Enhances Cognitive Function*
Read the entire label and follow the directions carefully prior to use.
DIRECTIONS: Take three (3) softgels in the morning with or without food. Some people may take three (3) softgels twice daily, or as recommended by a healthcare practitioner.
Serving Size 3 Softgels Servings Per Container 30
Amount Per Serving % Daily Value
Alpha-Glyceryl Phosphoryl Choline (A-GPC) 600 mg **
Phosphatidylserine 100 mg **
[Sharp-PS® GOLD Conjugated Phosphatidylserine-DHA] Vinpocetine 20 mg **
Leucoselect® Phytosome™ [containing 50 mg grape seed 150 mg **
(Vitis vinifera) procyanidin extract complexed with soy (Glycine max) phospholipids (bean)] BlueActivTM Wild Blueberry (Vaccinium angustifolium) 150 mg **
Anthocyanins extract (fruit) Sensoril® Ashwagandha (Withania somnifera) extract 125 mg **
(root and leaves) [standardized to 8% withanolide glycoside conjugates (10 mg)]
Uridine-5'-Monophosphate (disodium) 50 mg **
Proprietary NeuroProtection Complex Blend 125 mg **
Perluxan® Hops (Humulus lupulus) Standardized extract (cones), Ginger (Zingiber officinale) Standardized extract (rhizome), Rosemary (Rosmarinus officinalis) Standardized extract (leaves)
**Daily Value not established
Other ingredients: rice bran oil, gelatin, glycerin, soy lecithin, purified water, sorbitol, maltodextrin, carob color, silica, modified food starch. Contains fish (wild herring, blue whiting) and soybeans. Contains corn and rice.
CAUTION: If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product.
• KEEP OUT OF REACH OF CHILDREN.
• DO NOT EXCEED RECOMMENDED DOSE.
• Do not purchase if outer seal is broken or damaged.
• When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating
*Your results may vary from those listed above.
*These statements have not been evaluated by the Food and Drug Administration.
*This product is not intended to diagnose, treat, cure or prevent any disease.
Since we do not know everything about your medical history and medications, please consult with your health care practitioner before implementing any new protocols and supplements. Do not construe any information listed on this site as a substitute for actual medical advice. The info you receive from us is not intended to replace medical advice by your doctor. Forrest Health, Inc. does not dispense medical advice, prescribe, or diagnose illness. We offer nutritional programs and supplements that support your health. The views and nutritional advice expressed by Forrest Health, Inc. are not intended to be a substitute for conventional medical service. If you have a medical condition, see your physician of choice.