Cerelist

Cerelist | NeuroScience

Alzheimer's disease is the most common cause of dementia among older people, affecting about 5.1 million Americans. Mild cognitive impairment (MCI) is an established risk factor for Alzheimer's disease.

Cerelist provides support for the synthesis of acetylcholine, a neurotransmitter essential for cognitive function and memory. Acetyl-L-carnitine and Alpha-glycerylphosphorylcholine (α-GPC) are precursor components necessary for acetylcholine synthesis. Additional nutrients meet the high energy demands and protect the integrity of brain cells by serving as metabolic cofactors, structural components, and free-radical scavengers. .

	Protects Neuronal Cells	Supports Brain Cell Metabolism	Provides cholinergic support
			Promotes acetylcholine synthesis	Reduces breakdown of acetylcholine
Cerelist*
Zymenta*

Both Zymenta and Cerelist are indicated for MCI and mild-to-moderate Alzheimer's disease. Cerelist is ideal as an add-on for patients already taking an acetylcholinesterase inhibitor.

	Cerelist	Zymenta	Mechanism of Action
Huperzine A			Inhibits acetylcholinesterase. Reduces pro-inflammatory cytokines and prevents glutamate excitotoxicity.1-3
a-GPC			Crosses blood-brain barrier to support neuronal cell structure and function. Provides choline, a precursor for ACh synthesis.4-7
Acetyl-L-carnitine			Provides an acetyl group - a precursor for ACh synthesis.
a-lipoic acid			Imparts synergistic antioxidant effects.8
Choline bitartrate			Ensures that choline intake is adequate to meet peripheral demands.
B vitamins			Prevent the deficiencies in folate, B12, and B6 that can alter choline metabolism and increase choline demand.9-12

Key Ingredients:

• Acetyl-L-carnitine provides precursor support for acetylcholine synthesis as well as facilitates brain cell energy metabolism and protects against free-radical damage to neurons.
• Alpha-glycerylphosphorylcholine (α-GPC) provides precursor support for acetylcholine synthesis and serves as a structural component of brain cell membranes.^1-4
• Choline bitartrate helps meet peripheral demands for choline without drawing from the central nervous system supply.
• Alpha-lipoic acid enables glucose uptake into brain cells and in combination with acetyl-L-carnitine, offers antioxidant protection against free radicals .⁵

1. Mason JB. J Nutr 2003;133Suppl 3:941S-7S.
2. Wollen KA. Altern Med Rev 2010;15:223-44.
3. Wang R, et al. ActaPharmacol Sin 2006; 27:1-26.
4. Swardfager W, et al. Biol Psychiatry 2010.
5. Kohlmeier M, et al. ProcNatlAcadSci U S A 2005;102:16025-30