5 MTHF Activated

5 MTHF Activated
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30 vcaps
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5 MTHF Activated 30 vcaps | BioGenesis

5 MTHF Activated  contains Quatrefolic® (glucosamine salt) fourth/newest generation folate with long-lasting stability, high water solubility, improved bioavailability and well-established safety 

  • May support healthy levels of dopamine and serotonin
  • May support healthy levels of homocysteine
  • Supplies 5,000 mcg 5-methyltetrahydrofolate


- May support healthy levels of homocysteine†
- Is seven times more bioavailable than folic acid†
- May support healthy levels of dopamine and serotonin†

5 MTHF ACTIVATED contains a bioactive and bioavailable form of folic acid known as 5-methyltetrahydrofolate. This form of folic acid is considered active because it is the form that is directly incorporated into the methylation cycle that converts homocysteine to methionine. It is also 7 times more bioavailable than regular folic acid. Without adequate 5 MTHF, the inflammatory compound homocysteine can build up in the blood vessels. Also, this methyl-group donation is vital to many bodily processes, including the synthesis of serotonin, melatonin and DNA.†

There are many reasons why folate deficiency is considered one of the most common nutritional deficiencies. These include deficiency in the food supply, defects in utilization as in alcoholics or those with liver disease, malabsorption, increased needs in pregnant and nursing women, metabolic interference by drugs, and deficiencies in enzymes or cofactors needed for the generation of active folic acid.

In order for folate to be converted to its active form in the body, several enzymes, adequate liver and intestinal function and sufficient amounts of riboflavin (B2), niacin (B3), pyridoxine (B6), zinc, vitamin C and serine need to be present. Significantly greater amounts of folate were found in the serum after 24 weeks of supplementation with 5 MTHF than with folic acid and placebo. This may be because at least 25% of the population may have an enzyme defect, or single nucleotide polymorphism (SNP), that leads to a decrease in the function of the methylenetetrahydrofolate reductase (5 MTHFR) enzyme, which is needed to convert folic acid into its active form, 5 MTHF.*

Signs and symptoms of folate deficiency include elevated homocysteine, macrocytic anemia, fatigue, irritability, peripheral neuropathy, hyper-reflexivity, restless legs syndrome, diarrhea, weight loss, insomnia, depression, dementia cognitive disturbances, and psychiatric disorders.*

CARDIOVASCULAR DISEASE: High levels of homocysteine have been implicated in many different disorders of the cardiovascular system, including thrombosis, stroke, atherosclerosis, and myocardial infarction. As well as decreasing homocysteine levels in the blood, 5 MTHF also improves peripheral blood flow in the arteries by increasing nitric oxide (NO) production in the vascular endothelium. Most of the risk factors for atherosclerosis are associated with poor vasodilation due to insufficient NO production. In a six-week, randomized, crossover study of 52 individuals with coronary artery disease, folic acid at a dose of 5 mg/day significantly improved flow-mediated dilation, a measurement of endothelial function. This was independent of the homocysteine level in the blood.*

INFLAMMATORY BOWEL DISEASE: Folate deficiency is common in those with inflammatory bowel disease, partly caused by the drug sulfasalazine, which is known to inhibit folate absorption. Evidence from a study of patients with ulcerative colitis shows that folic acid supplementation lowers the risk of colonic neoplasia in a dose-dependent fashion. The relative risk of developing neoplasia was 0.76 for 400 mcg folate and 0.54 for 1 mg folate for at least six months compared to placebo.

5 MTHF Activated 30 vcaps | BioGenesis

Suggested Use: As a dietary supplement, take one capsule per day or as directed by your healthcare professional. Dose may be repeated if necessary.

Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 30
Amount per Serving
Folate (as 5-MTHF glucosamine salt)(Quatrefolic®) 5,000 mcg
Other Ingredients: Rice flour and hypromellose.

If pregnant or breastfeeding, consult your healthcare professional before use. Keep tightly capped and store in a cool, dry place. KEEP OUT OF REACH OF CHILDREN. Do not use if either tamper-evident seal is broken or missing

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Your results may vary from those listed above.

These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.

Since we do not know everything about your medical history and medications, please consult with your health care practitioner before implementing any new protocols and supplements. Do not construe any information listed on this site as a substitute for actual medical advice. The info you receive from us is not intended to replace medical advice by your doctor. Forrest Health, Inc. does not dispense medical advice, prescribe, or diagnose illness. We offer nutritional programs and supplements that support your health. The views and nutritional advice expressed by Forrest Health, Inc. are not intended to be a substitute for conventional medical service. If you have a medical condition, see your physician of choice